This is a pitch perfect adaptation, for once I have no major or even moderate quibbles with the show and I actually now prefer many of it's segments to the original 4koma. The source material really is great (and I've peeked at the manga-ka's other major work, Oresama Teacher, published in the US by Viz, and it also seems to have the same madcap, out-there style of humor) but the anime did an amazing job at translating sections of four square images into full fledged scenes and all of the sound effects, music, acting, and even the color and more detailed backgrounds add to it. Plus, if you mention any of those things you'll invertible be reminded of a gag or two from the series, I was initially afraid that people who didn't read as much shojo wouldn't get all the jokes but it's remarkably accessible and if you've been an anime/manga fan for a couple of years you'll have no trouble seeing what ideas they're playing with and parodying.
Unlike some other humor shows, the gags in Nozaki-kun come almost exclusively from character actions and interactions with each other, not from the characters noticing and interacting with something in their setting (unlike Haikyuu!! from last week or G.A. Art Design Class which have both kinds). It does all of this without being mean-spirited, we're not laughing that Kashima gets mistaken for being a prince (a guy) more often than people realize she's a girl but at how she's completely charmed her classmates to the point that they would rather flirt with her than actual guys at a mixer!* Josei Next Door talks even more about the gender-bending that goes on in the show (stereotype-wise anyway) and this seems like a good point to mention a detail that many people didn't know going into the show, despite how much it lampoons shojo manga tropes this is from a shonen manga. Abet one that has a bit of a wider readership to start with but I think this is also a sign of just how solidly Izumi Tsubaki gets the humor and not just that. Not only does the story flow easily when neither Nozaki nor Sakura are on screen but none of the situations would work if you replaced one character with another, every character has a well-defined personality and faults that lend themselves better to some situations than others, although if you match up any two characters you'll be sure to get something funny.
In short, if you are a regular reader of this blog then this series will be right up your alley and even if you aren't I recommend giving the series a shot, it's only 12 episodes, streaming on crunchyroll and hulu, and Sentai Filmworks has picked it up for a physical release in the US. The manga isn't licensed yet and while there hasn't been a second season announcement for the anime yet I'm optimistic, the anime has sold well and given the manga sales in Japan a nice bump which is always a good sign. And I do highly recommend G.A. Art Design Class and think that a lot of Nozaki-kun fans who liked the art gags would really enjoy, it's also only 12 episodes and on crunchyroll so that can help fill the gap for a little bit at least!
*I saw someone, I've forgotten who, propose that the reason we see so many of the girls going along with Kashima and Mikorin's flirtations, and so happily, is because of how "safe" these two characters are, Kashima clearly doesn't have any intention to seduce these girls into a real romantic relationship and there have got to be other people than the Nozaki-assistant-gang that have noticed that Mikorin turns into a puddle of embarrassment each time he says something cool. And I rather like that idea since it fits into one of the general themes of Nozaki-kun, real life isn't very romantic and rather silly to boot, and these silly friend-flirtations certainly match up with what I've seen some of my mostly-straight groups of girl-friends do before (I would say I've seen some of my guy friends do this as well and then I remember just how queer my group of friends is).